Stop cramps from spilling over, keep your period tummy flatter
If bloating always shows up before your cramps, it’s not just your diet, hormones, or digestion. It’s the same three triggers behind period cramps spilling over,
making you feel heavier and more bloated before your period even starts.
Less period bloating and weight swings*
Ease period cramps, cravings, and PMS*
The UK’s first and most complete formula
By 5 women’s health doctors and experts
90-DAY MONEY BACK GUARANTEE
Hundreds of women are already feeling lighter — with less bloating, pain, and fatigue
Maria R.
“After just a few weeks of taking monthlies I’ve noticed a significant improvement in how I feel during my cycle. The cramps that used to keep me curled up on the couch are now much more manageable, and the bloating I dreaded every month has drastically reduced. I also have fewer mood swings and way more energy, even during my toughest days.”
Review from Trustpilot, Verified Buyer
Louise W.
“This supplement has significantly improved my quality of life. The biggest benefits for me are 1) reduction in bloating 2) stabilized mood, and 3) less hair loss. Overall, I now feel more physically balanced. Many thanks, monthlies!”
Review from Trustpilot, Verified Buyer
Elizabeta M.
"I’m just finishing my second month and I can only say that my symptoms have reduced dramatically. After quitting my birth control pills, my pain got back and I needed to take painkillers all the time. To be honest, I completely lost faith that something else could help. I can only say, very worth the price. Thanks monthlies for bringing my life back!"
Review from Trustpilot, Verified Buyer
Claudia Y.
“I’ve been using monthlies and am beyond impressed. For years, I thought period pain was something I had to live with—it disrupted my life so much that even basic tasks felt impossible. Now, not only is the pain completely gone, but I also feel more energized, sleep better, and notice improved performance in my daily life. It’s amazing to finally live without suffering. Highly recommend!”
Review from Trustpilot, Verified Buyer
The Problem
Period bloating, weight swings, food cravings, and fatigue… what’s the deal with cramp spillovers?
“Cramp spillovers” happen when the same three triggers behind period pain start affecting your body before cramps hit —leading to bloating, cravings, and PMS symptoms.
Here’s the thing — mild cramps are a natural part of shedding your lining each month. But when their triggers run too wild, the spillover becomes the real reason so many women struggle with their cycles.
Trigger #1 - Imbalanced Hormones
"Rapid declines in estrogen and progesterone have been associated with a constellation of symptoms, including pain, bloating, and mood changes."
Source: American Journal of Physiology, 2005.
Trigger #2 - Prostaglandins
"Women with painful cramps have over three times higher prostaglandin levels, which strongly correlate with more intense uterine contractions and related symptoms such as bloating."
Source: Lundström & Green (1978).
Trigger #3 - Inflammation
"Symptoms of PMS are associated with elevated C-reactive protein (CRP). Elevated CRP levels indicate a state of low-grade inflammation, contributing to symptoms such as cramps, back pain, weight gain, and bloating."
Source: Eur J Clin Invest, 2006.
So, what does this mean?
If your bloating doesn’t follow a cycle-related pattern and doesn’t show up in the week or two before your period, then these three triggers likely aren’t the cause.
But if you consistently feel bloated, heavier, or experience sudden weight swings and cravings before your period starts, no restrictive diets, exercise alone, or standard debloating supplements will fix it — because they don’t address the root of the issue.
The good news?
Leading menstrual health specialists have found that by tackling all three triggers at once, you can prevent period bloating, stabilize weight fluctuations, and finally reduce PMS and painful cramps.*
For references and/or sources, click here
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
The Solution
The first supplement designed to targetthree triggers of period bloating and weight gain — helping you maintain a flatter stomach and tackle period bloating for good*
Created by five female doctors and women’s health experts after personally helping over 2,500 women escape period bloating and discomfort at their clinics, monthlies brings together 26 of the most advanced natural compounds to help tackle the tri-factor of period bloating.*
Balance Your Hormones*
What happens?
Your hormones naturally rise and fall each month, but when oestrogen climbs too high — often due to stress, hectic schedules, poor sleep, or diet — it can throw your whole system off balance. This leads to water retention, slower digestion, and sudden bloating or weight swings.
On top of that, excess oestrogen increases prostaglandin production, causing spillovers that amplify bloating, fluid retention, and gut discomfort before cramps even start. These shifts also drive cravings, making you more likely to reach for foods that worsen bloating.
The result? A bloated, puffy feeling before your period, excess weight fluctuations, intense food cravings, and a body that feels out of balance.
How monthlies helps:
Formulated with scientifically backed ingredients like Lemon Balm, Broccoli Seed Extract, the B-Complex, Myo-Inositol, Choline, and Flaxseed, monthlies supports hormonal balance at its core — helping to regulate estrogen metabolism, reduce fluid retention, and support digestion.*
By keeping these pathways in check, it also helps prevent the spillover effect, where hormonal imbalances amplify bloating, puffiness, and unpredictable weight swings — while also taming food cravings that drive bloating even further. The result? Feeling lighter, more in control, and balanced throughout your cycle.
For references and/or sources, click here
The first supplement to
support your HPO axis & bring
symptomatic comfort
monthlies is the first formula to feature 26 science-backed ingredients selected by our female doctors to target both the symptoms and the root cause to provide ease that’s predictable, lasting, and complete:
Reduce Period Pain*
Cramping happens when prostaglandins cause your uterus to contract. More prostaglandins = more intense pain.
monthlies supports your HPO axis with myo-inositol, flaxseed, and broccoli seed extract to promote hormonal balance and lower prostaglandin activity.
Ginger, aniseed, and turmeric have been shown in studies* to provide targeted ease from pain and inflammation (hello natural comfort!) without the downsides of painkillers.
* See Study References
By Women's Health Experts
Our experts cracked the
code for women who had
already tried everything
Our experts cracked the code for women who had already tried everything
After helping thousands of women over a decade, we realised there wasn’t a product that addressed the root cause of menstrual symptoms while offering targeted support.
So, we took everything that worked and crafted it into one simple, once-a-day, delicious drink - monthlies.
Dr. Ashley Florestal
B. Comm, ND, Canadian College of
Naturopathic Medicine, Concordia University
“What I love about monthlies is its comprehensive yet targeted approach. The formula doesn’t just support with period pain — it nourishes the entire hormonal system. My patients often share that they experience less intense periods, better sleep, improved energy, and more stable moods. This is the power of effectively supporting women’s bodies and hormones."
Dr. Ashley Florestal
B. Comm, ND, Canadian College of Naturopathic Medicine, Concordia University
“What I love about monthlies is its comprehensive yet targeted approach. The formula doesn’t just support with period pain — it nourishes the entire hormonal system. My patients often share that they experience less intense periods, better sleep, improved energy, and more stable moods. This is the power of effectively supporting women’s bodies and hormones."
Dr. Maria Obando
MD, Esp, IFMCP-
Los Andes University
“The HPO axis—your hypothalamus, pituitary, and ovarian system—is the foundation of hormonal health. monthlies supports this vital system with 26 science-backed, natural ingredients, addressing root causes of symptoms like period pain, bloating, fatigue, and mood swings. It truly is a one-stop solution for menstrual wellness.”
Dr. Cassandra Paiano
BSc, ND
“No two women experience their cycles the same way, which is why I appreciate the versatility of monthlies. Its formula is designed to address a variety of symptoms—from period pain and digestive discomfort to lack of energy and mood swings. This adaptability makes it a comprehensive solution for women seeking better menstrual health.”
Geneva Sade
DipNT, mANP, The College of Naturopathic Medicine
“No two women experience their cycles the same way, which is why I appreciate the versatility of monthlies. Its formula is designed to address a variety of symptoms—from period pain and digestive discomfort to lack of energy and mood swings. This adaptability makes it a comprehensive solution for women seeking better menstrual health.”
Melissa Mastroberardino
RHN, ND, Canada College of Natural Nutrition, Concordia University
“It’s astonishing how many women believe period pain is normal and ‘just part of being a woman.’ When women think of health, they often focus on weight, digestion, or skin, but rarely on cycles. monthlies takes a fresh approach by prioritising menstrual wellness, helping women understand their cycles while supporting their bodies to restore balance naturally.”
Fast and free 1 to 2 day shipping
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
The Most Complete Formula
Tackle the root cause of period bloating along with frustrating cycle and PMS symptoms*
Around 90% of people who menstruate struggle with PMS symptoms. That's why we didn't stop at bloating, but created the UK's most advanced and comprehensive women's health formula.
Soothes
bloating*
Helps calm
cramps*
Fewer mood
swings*
Helps in weight control & satiety*
Boost energy
& motivation*
Hormonal
harmony*
Helps tame
food cravings*
Better sleep,
less stress*
* See Ingredients
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Monthly Subscription
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Month’s supply of monthlies
Save 33% every single month
90-day money back guarantee
FREE shipping on every order
FREE 1-1 doctor consultation
every month (worth £100)
FREE exercise, nutrition, and
cycle guide (worth £50)
Cancel anytime
Delivered every 30 days (free shipping).
£35.00 (£50.00)
Cancel at any time - Free returns - Instant refunds
One-time Purchase
Tropical Flavour
NO money back guarantee
Month’s supply of monthlies
FREE shipping on your order
FREE exercise, nutrition, and
cycle guide (worth £50)
£50.00
Cancel at any time - Free returns - Instant refunds
Our trusted payment processors:
Choose Your Package Below
Monthly Subscription
LIMITED TIME - SAVE 33%
Tropical Flavour
Monthly supply of monthlies
Save 33% every single month
90-day money back guarantee
FREE shipping on every order
FREE 1-1 doctor consultation
every month (worth £100)
FREE exercise, nutrition, and
cycle guide (worth £50)
Cancel anytime
Delivered every 30 days (free shipping).
£35.00 (£50.00)
Cancel at any time - Free returns - Instant refunds
One-time Purchase
Tropical Flavour
NO money back guarantee
Monthly supply of monthlies
FREE shipping on your order
FREE exercise, nutrition, and
cycle guide (worth £50)
£50.00
Our trusted payment processors:
What to expect
Your first cycle
What to expect:
In the first cycle, your body starts replenishing key nutrients, supporting steadier energy, better sleep, and a more balanced mood. Early hormonal adjustments can also begin easing bloating and digestive sluggishness, as oestrogen metabolism and fluid regulation start to normalise. These initial shifts set the stage for deeper hormonal recalibration in the coming months, as your body regulates through complex endocrine feedback loops.*
We've accounted for
periods as a whole
Carefully picked by women’s health experts, monthlies features premium, third-party tested ingredients in their most active and highly absorbable forms — ensuring purity, potency, and unmatched quality.
To fit all 26 ingredients in pill form, you'd need to take 16 pills a day. monthlies is the simplest, safest, and most effective way to ensure you're getting everything you need — for less than £1.30 per day at the lowest.
Simply mix one scoop of monthlies into water in the morning, and you’re good to go!
Optimal results are seen after 3 months
Plant Extracts
Lemon Balm
Lemon balm has been shown to promote relaxation and reduce stress by modulating mood and cognitive function. It may exert calming effects on the central nervous system, potentially through its influence on GABAergic activity.*
Helps: Promotes a calm mood, supports relaxation, and aids in managing occasional bloating.*
Broccoli Seed Extract
Broccoli seed extract contains glucoraphanin, which metabolizes into sulforaphane. Sulforaphane influences estrogen metabolism by promoting a favorable 2:16 hydroxyestrone ratio, supporting hormonal detoxification and balance.*
Helps: Encourages hormonal balance, supports estrogen metabolism, and promotes comfort during hormonal fluctuations*
Flaxseed
Flaxseed is rich in lignans, which act as phytoestrogens. These compounds may help modulate estrogen levels, support progesterone balance during the luteal phase, and improve menstrual cycle regularity. Additionally, flaxseed may help manage weight swings and reduce cravings and appetite fluctuations associated with hormonal changes. The high fiber content in flaxseed promotes satiety, potentially leading to decreased calorie intake and better appetite control.*
Helps: Supports hormonal balance, aids in managing occasional bloating, promotes menstrual cycle comfort, and may assist in weight management by reducing cravings and appetite fluctuations.*
Ginger Root Extract
Ginger contains bioactive compounds like gingerols and shogaols that inhibit prostaglandin synthesis via COX and LOX pathways. This anti-inflammatory action helps reduce menstrual cramps and digestive discomfort.
Helps: Aids in managing occasional cramps, supports digestive wellness, and promotes natural cycle comfort.*
Aniseed Extract
Aniseed has carminative and antispasmodic properties that relax gastrointestinal muscles, alleviating bloating, cramps, and other digestive discomforts.
Helps: Promotes soothing comfort during cyces, supports digestion, and eases occasional tension.*
Turmeric Root Extract
Curcumin in turmeric has anti-inflammatory properties that help reduce menstrual discomfort by targeting inflammatory pathways and promoting bile production to alleviate bloating.*
Helps: Promotes comfort during cycles, supports natural inflammation balance, and aids in managing bloating.*
Vitamin Complex
Vitamin B Octa-Complex (B1, B2, B3, B5, B6, B7, B9, B12)
Contributes to energy production, hormone regulation, and mood support.*
Helps: Boosts energy, stabilises mood, and supports healthy hormone function.*
Vitamin C
Supports skin health and immune system function.*
Helps: Promotes healthier skin and helps protect against oxidative stress.*
Vitamin D3 + K2
Known to support bone health and calcium metabolism.*
Helps: Strengthens bones and supports hormone balance.*
Vitamin A
Contributes to skin clarity and overall health.*
Helps: Supports clearer skin and assists in healthy hormonal function.*
Minerals
Magnesium
Known for its role in muscle relaxation and energy support.*
Helps: Promotes muscle comfort, aids in managing occasional bloating, and encourages relaxation.*
Calcium
Supports muscle and nerve function while helping regulate mood.*
Helps: Eases uterine tension and supports mood stability.*
Zinc
Plays a role in hormone regulation and skin health.*
Helps: Promotes clear skin, healthier hair, and hormone balance.*
Iron
Essential for energy production and oxygen transport.*
Helps: Supports energy levels and reduces fatigue.*
Chromium
Aids in blood sugar regulation and appetite control.*
Helps: Supports reduced cravings and balanced energy levels.*
Selenium
Provides antioxidant support for overall cellular health.*
Helps: Protects cells from oxidative stress and supports healthy nails and hair.*
Nutrients
Myo-Inositol
Myo-inositol is a naturally occurring compound that plays a vital role in cellular signaling and hormone response. It helps support insulin sensitivity and proper glucose metabolism, which may contribute to hormonal balance and regular ovulation. Additionally, myo-inositol aids in maintaining healthy hormone receptor function and cellular communication pathways essential for reproductive health.*
Helps: Supports hormonal balance, promotes regular cycles, aids in maintaining healthy insulin function, and may help manage occasional cravings and appetite fluctuations.*
Choline
Helps support brain and hormonal health.*
Helps: Enhances focus and contributes to hormonal balance.*
Beta-Carotene
A precursor to vitamin A, supporting skin and hormonal health.*
Helps: Contributes to a radiant complexion and supports overall balance.*
Amino Acids
L-Glutamine
Supports gut function and helps maintain digestive comfort.*
Helps: Promotes digestive well-being and supports occasional bloating relief.*
See Full Ingredients
We've accounted for
periods as a whole
Carefully picked by women’s health experts, monthlies features premium, third-party tested ingredients in their most active and highly absorbable forms — ensuring purity, potency, and unmatched quality.
To fit all 26 ingredients in pill form, you'd need to take 16 pills a day. monthlies is the simplest, safest, and most effective way to ensure you're getting everything you need — for less than £1.30 per day at the lowest.
Simply mix one scoop of monthlies into water in the morning, and you’re good to go!
Plant Extracts
Lemon Balm
Lemon balm has been shown to promote relaxation and reduce stress by modulating mood and cognitive function. It may exert calming effects on the central nervous system, potentially through its influence on GABAergic activity.*
Helps: Promotes a calm mood, supports relaxation, and aids in managing occasional bloating.*
Broccoli Seed Extract
Broccoli seed extract contains glucoraphanin, which metabolizes into sulforaphane. Sulforaphane influences estrogen metabolism by promoting a favorable 2:16 hydroxyestrone ratio, supporting hormonal detoxification and balance.*
Helps: Encourages hormonal balance, supports estrogen metabolism, and promotes comfort during hormonal fluctuations*
Flaxseed
Flaxseed is rich in lignans, which act as phytoestrogens. These compounds may help modulate estrogen levels, support progesterone balance during the luteal phase, and improve menstrual cycle regularity. Additionally, flaxseed may help manage weight swings and reduce cravings and appetite fluctuations associated with hormonal changes. The high fiber content in flaxseed promotes satiety, potentially leading to decreased calorie intake and better appetite control.*
Helps: Supports hormonal balance, aids in managing occasional bloating, promotes menstrual cycle comfort, and may assist in weight management by reducing cravings and appetite fluctuations.*
Ginger Root Extract
Ginger contains bioactive compounds like gingerols and shogaols that inhibit prostaglandin synthesis via COX and LOX pathways. This anti-inflammatory action helps reduce menstrual cramps and digestive discomfort.
Helps: Aids in managing occasional cramps, supports digestive wellness, and promotes natural cycle comfort.*
Aniseed Extract
Aniseed has carminative and antispasmodic properties that relax gastrointestinal muscles, alleviating bloating, cramps, and other digestive discomforts.
Helps: Promotes soothing comfort during cyces, supports digestion, and eases occasional tension.*
Turmeric Root Extract
Curcumin in turmeric has anti-inflammatory properties that help reduce menstrual discomfort by targeting inflammatory pathways and promoting bile production to alleviate bloating.*
Helps: Promotes comfort during cycles, supports natural inflammation balance, and aids in managing bloating.*
Vitamin Complex
Vitamin B Octa-Complex (B1, B2, B3, B5, B6, B7, B9, B12)
Contributes to energy production, hormone regulation, and mood support.*
Helps: Boosts energy, stabilises mood, and supports healthy hormone function.*
Vitamin C
Supports skin health and immune system function.*
Helps: Promotes healthier skin and helps protect against oxidative stress.*
Vitamin D3 + K2
Known to support bone health and calcium metabolism.*
Helps: Strengthens bones and supports hormone balance.*
Vitamin A
Contributes to skin clarity and overall health.*
Helps: Supports clearer skin and assists in healthy hormonal function.*
Minerals
Magnesium
Known for its role in muscle relaxation and energy support.*
Helps: Promotes muscle comfort, aids in managing occasional bloating, and encourages relaxation.*
Calcium
Supports muscle and nerve function while helping regulate mood.*
Helps: Eases uterine tension and supports mood stability.*
Zinc
Plays a role in hormone regulation and skin health.*
Helps: Promotes clear skin, healthier hair, and hormone balance.*
Iron
Essential for energy production and oxygen transport.*
Helps: Supports energy levels and reduces fatigue.*
Chromium
Aids in blood sugar regulation and appetite control.*
Helps: Supports reduced cravings and balanced energy levels.*
Selenium
Provides antioxidant support for overall cellular health.*
Helps: Protects cells from oxidative stress and supports healthy nails and hair.*
Nutrients
Myo-Inositol
Myo-inositol is a naturally occurring compound that plays a vital role in cellular signaling and hormone response. It helps support insulin sensitivity and proper glucose metabolism, which may contribute to hormonal balance and regular ovulation. Additionally, myo-inositol aids in maintaining healthy hormone receptor function and cellular communication pathways essential for reproductive health.*
Helps: Supports hormonal balance, promotes regular cycles, aids in maintaining healthy insulin function, and may help manage occasional cravings and appetite fluctuations.*
Choline
Helps support brain and hormonal health.*
Helps: Enhances focus and contributes to hormonal balance.*
Beta-Carotene
A precursor to vitamin A, supporting skin and hormonal health.*
Helps: Contributes to a radiant complexion and supports overall balance.*
Amino Acids
L-Glutamine
Supports gut function and helps maintain digestive comfort.*
Helps: Promotes digestive well-being and supports occasional bloating relief.*
See Full Ingredients
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We're transforming women's wellness by combining science-backed ingredients with expert guidance from professionals who understand. Access proven protocols, get personalized support, and target both root causes and symptoms.
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1. Monthly 1-1 Consultation
Connect directly with our women's health professionals - the same ones who've helped 2,500 women transform their cycle wellness. Get exclusive guidance from your couch, on your schedule.
Consult our wellness experts privately
Monthly 30-min call at your convenience
Personalized tips beyond supplements
Booking details sent via email after subscribing. Consultations are optional, but we include them because we understand how often period concerns get overlooked.
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FAQS
How fast will I see results?
Most women notice improvements in energy, mood, and digestion within the first few weeks. Because hormones operate on intricate feedback loops, more significant changes, like potential ease from cramps or bloating, often require 2-3 cycles. This allows monthlies to work with your body’s natural rhythms for lasting results.
What is the HPO axis, and why is it important?
The HPO axis stands for the Hypothalamus-Pituitary-Ovarian axis, and it’s like your body’s hormonal command centre. Here’s how it works:
Hypothalamus (The Coordinator): This part of your brain sends out signals (called GnRH) to kickstart hormone production. It’s also highly sensitive to stress, sleep, and nutrition, which can disrupt the entire process.
Pituitary Gland (The Messenger): The pituitary gland receives signals from the hypothalamus and produces key hormones like FSH (follicle-stimulating hormone) and LH (luteinizing hormone). These control your cycle rhythm and regulate things like water retention and sugar metabolism.
Ovaries (The Hormone Producers): Your ovaries respond to the pituitary gland’s signals by producing estrogen and progesterone. These hormones are responsible for managing symptoms like cramps, mood swings, and bloating, as well as regulating prostaglandins, which can cause pain during your period.
When this system is in balance, your body works smoothly. But when it’s thrown off by factors like stress, nutrient gaps, or lifestyle changes, the feedback loops misfire. This can cause your body to overreact, leading to bloating, pain, mood swings, fatigue, and other cycle-related symptoms.
When and how should I take monthlies?
Take monthlies once daily in the morning with food. Simply mix one scoop with water or your favourite beverage. Consistent use is essential to experience the full benefits, as it works with your body’s natural cycles.*
What if I only struggle with X but not Y or Z?
monthlies is designed to address both current symptoms and long-term hormonal health. Many women report feeling more balanced, energetic, and focused within weeks, even if they initially only struggled with one or two “main” symptoms. Its targeted nutrients also work to prevent future flare-ups or new issues from arising, supporting overall well-being.*
Can I start taking it at any point of my cycle?
Yes, you can start taking monthlies at any point in your cycle.
What does the 90-day guarantee mean?
Most women notice an energy boost from Monthlies within days, then experience fewer and less intense cramps, less bloating, more stable moods, and better sleep during their second cycle after starting. Some feel these changes sooner, others might take a bit longer - as every woman's cycle is unique.
That's why we encourage you to try it yourself. If you don't feel more energized and in control, with less bloating and pain, you have 90 days to claim a full refund of your first order. Simply email us at returns@withmonthlies.com without giving any further reason.
Can I take monthlies if I use birth control?
While you can certainly take monthlies powder for its potential benefits, it's important to note that hormonal contraceptives, such as implants and pills, can affect hormone levels.
Since hormonal contraceptives regulate your hormone balance, the efficacy of the powder might be compromised by the contraceptive method you are using.
Disclaimer:
The information provided on this website, through our products, and during consultations is intended for general wellness and educational purposes only. This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition. The claims made here have not been evaluated by any regulatory authority.
Our health professionals and consultations are designed to provide general wellness guidance and should not replace advice from your healthcare provider. Always consult with a physician, pharmacist, or other qualified healthcare professional for questions regarding your health, medications, or specific medical conditions.
Important Information on Use:
1. Results may vary based on individual factors such as starting health, lifestyle, adherence to recommendations, and other unique circumstances.
2. Proper diet, exercise, and hydration are essential for achieving and maintaining health benefits.
3. If you are pregnant, breastfeeding, taking medications, or have an existing medical condition, consult your healthcare provider before using monthlies or any other supplements.
Study References:
The impact of menstrual symptoms on everyday life: a survey among 42,879 women Harlow, S. D., & Park, M. (1996). American Journal of Obstetrics and Gynecology, 174(2), 683-689. https://www.ajog.org/article/S0002-9378(19)30427-2/abstract
NSAID Resistance in Dysmenorrhea: Epidemiology, Causes, and Treatment Options
"A review of 51 clinical trials found that 18% of women report minimal or no relief of menstrual pain with NSAIDs." https://pmc.ncbi.nlm.nih.gov/articles/PMC5839921/
NSAID use is associated with increased risk of acute kidney injury, particularly in older adults and those with chronic conditions. https://bjgpopen.org/content/6/1/BJGPO.2021.0208.long
Women with dysmenorrhea using NSAIDs had a 2.29-fold higher risk of stroke with prolonged use (≥24 days/month). https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0259047
32% of women using NSAIDs for period pain reported gastrointestinal side effects, including nausea, ulcers, and diarrhea."
https://bmjopen.bmj.com/content/14/6/e079660
Stanford University researchers found that ibuprofen use during ultramarathons doubled the risk of acute kidney injury compared to a placebo. For every five runners taking ibuprofen, one additional case of kidney injury occurred. https://med.stanford.edu/news/all-news/2017/07/pain-reliever-linked-to-kidney-injury-in-endurance-runners.html
Chronic Stress and Ovulatory Dysfunction: Implications in Times of COVID-19 Vigil, P., Meléndez, J., Soto, H., Petkovic, G., Bernal, Y. A., & Molina, S. (2022). Frontiers in Global Women's Health, 3, Article 866104. https://www.frontiersin.org/journals/global-womens-health/articles/10.3389/fgwh.2022.866104/full
Micronutrient deficiencies among women of reproductive age: a global and regional assessment Kothari, M. T., et al. (2024). The Lancet Global Health, 12(1), e76-e84. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00276-6/fulltext
Houston, B. L., Hurrie, D., Graham, J., Perija, B., Rimmer, E., Rabbani, R., Bernstein, C. N., Turgeon, A. F., Fergusson, D. A., Houston, D. S., Abou-Setta, A. M., & Zarychanski, R. (2018). Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials. BMJ Open, 8(4), e019240. https://bmjopen.bmj.com/content/8/4/e019240
Ebrahimi, E., Khayati Motlagh, S., Nemati, S., Tavakoli, Z., & Hojat Yar, M. (2012). Effects of magnesium and vitamin B6 on the severity of premenstrual syndrome symptoms. Journal of Caring Sciences, 1(4), 183–189. https://pmc.ncbi.nlm.nih.gov/articles/PMC4161081/
Fathizadeh, N., Ebrahimi, E., Valiani, M., Tavakoli, N., Hojat Yar, M., & Hojat Yar, M. (2010). Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iranian Journal of Nursing and Midwifery Research, 15(Suppl1), 401–405. https://pmc.ncbi.nlm.nih.gov/articles/PMC3208934/#ref5
Wyatt, K. M., Dimmock, P. W., Jones, P. W., & O'Brien, P. M. (1999). Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ, 318(7195), 1375–1381. https://pmc.ncbi.nlm.nih.gov/articles/PMC27878/#sec14
James W. Daily, Ph.D., Xin Zhang, BS, Da Sol Kim, MS, Sunmin Park, Ph.D., Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials, Pain Medicine, Volume 16, Issue 12, December 2015, Pages 2243–2255, https://doi.org/10.1111/pme.12853
Rose, D. P. (1978). The interactions between vitamin B6 and hormones. Vitamins and Hormones, 36, 53–99. https://pubmed.ncbi.nlm.nih.gov/217175/
See all here.