The first supplement
for all four phases of
your menstrual cycle
Ease intense monthly cramps naturally*
Reduce mood swings, bloating, and PMS*
86% saw improved cycle health in 30 days*
Made by 5 menstrual health professionals
The most complete women's health formula
Fast and free 1 to 2 day shipping
* Based on an independent study
of 105 women aged 20 to 45 using
the monthlies supplement.
As seen in:
Dont take our word
for it, take hers!
Find out what women across the UK are saying about the breakthrough to tackle PMS symptoms and period pain, without relying on painkillers or birth control.
Claudia Y.
“I’ve been using monthlies and am beyond impressed. My period pain disrupted my life so much that even basic tasks felt impossible. Now, not only is the pain completely gone, but I also feel more energized, sleep better, and notice improved performance in my daily life. It’s amazing to finally live without suffering.”
From Trustpilot, Verified Buyer
Uditha T.
"I have seen a lot of immediate benefits in my first month of taking Monthlies! Definitely significantly less bloating & period pain. As soon I consumed monthlies during my cycle, the pain went away almost immediately. I also have a lot of energy in general on a daily basis, THANK YOU monthlies ❤️ I’m also really appreciative that each container has the necessary vitamins I need everyday, so I don’t really need any other supplements!"
From Trustpilot, Verified Buyer
Maria R.
“After just a few weeks of taking monthlies I’ve noticed a significant improvement in how I feel during my cycle. The cramps that used to keep me curled up on the couch are now much more manageable, and the bloating I dreaded every month has drastically reduced. I also have fewer mood swings and way more energy, even during my toughest days.”
From Trustpilot, Verified Buyer
Claudia Y.
“I’ve been using monthlies and am beyond impressed. My period pain disrupted my life so much that even basic tasks felt impossible. Now, not only is the pain completely gone, but I also feel more energized, sleep better, and notice improved performance in my daily life. It’s amazing to finally live without suffering.”
From Trustpilot, Verified Buyer
Uditha T.
"I have seen a lot of immediate benefits in my first month of taking Monthlies! Definitely significantly less bloating & period pain. As soon I consumed monthlies during my cycle, the pain went away almost immediately. I also have a lot of energy in general on a daily basis, THANK YOU monthlies ❤️ I’m also really appreciative that each container has the necessary vitamins I need everyday, so I don’t really need any other supplements!"
From Trustpilot, Verified Buyer
Maria R.
“After just a few weeks of taking monthlies I’ve noticed a significant improvement in how I feel during my cycle. The cramps that used to keep me curled up on the couch are now much more manageable, and the bloating I dreaded every month has drastically reduced. I also have fewer mood swings and way more energy, even during my toughest days.”
From Trustpilot, Verified Buyer
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
How Your Cycle Works
"Other women get to live their best lives - never missing work, fun, or exercise.... Why do I have to suffer from pain and PMS every single month?"
Your hormones operate on delicate feedback loops throughout your cycle, where one change triggers another... and another. When these loops get disrupted, it shows up as hormonal imbalance and worsened menstrual health, leading to:
Bloating &
Puffiness
Painful
Cramps
Low Energy
& Motivation
Unexpected
Weight Gain
Mood Swings
& Irritability
Food
Cravings
Issues
Sleeping
Irregular
Periods
To address the root cause of period pain and PMS naturally, you need to support your hormones in a tailored way through each phase. If just one phase is out of balance, it can disrupt the entire cycle, causing symptoms and discomfort
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
How monthlies Works
Tested in Clinics and Studies
with Thousands of Women
monthlies is formulated and tested by a team of 5 menstrual health professionals with over 10 years of hands-on experience treating even the most stubborn PMS symptoms and period pain in their clinics.
86%
saw improved cycle
health after 30 days*
80%
reported feeling less period
cramps and pain after 60 days*
* Based on an independent study of 105 women
aged 20 to 45 using the monthlies supplement.
The Menstruation Phase
What happens?
Hormone levels, including estrogen and progesterone, drop significantly, triggering the shedding of the uterine lining. This drop signals the release of prostaglandins, which cause the uterus to contract and shed its lining, resulting in cramps and inflammation. Women often feel bloating, intense cramps, low energy, and heightened mood sensitivity.
How monthlies helps:
Formulated with potent anti-inflammatory ingredients like Ginger Root Extract, Turmeric, and Aniseed, Monthlies targets inflammation and helps reduce uterine contractions. Magnesium supports muscle relaxation and reduces tension, while Vitamin B Complex aids in energy production and mood stabilization. The unique blend works to calm pain amplifiers at their source, helping ease cramps without the side effects associated with traditional painkillers.
Fast and free 1 to 2 day shipping
Tested in Clinics and Studies
with Thousands of Women
monthlies is formulated and tested by a team of 5 menstrual health professionals with over 10 years of hands-on experience treating even the most stubborn PMS symptoms and period pain in their clinics.
The Menstruation Phase
What happens?
Hormone levels, including estrogen and progesterone, drop significantly, triggering the shedding of the uterine lining. This drop signals the release of prostaglandins, which cause the uterus to contract and shed its lining, resulting in cramps and inflammation. Women often feel bloating, intense cramps, low energy, and heightened mood sensitivity.
How monthlies helps:
Formulated with potent anti-inflammatory ingredients like Ginger Root Extract, Turmeric, and Aniseed, Monthlies targets inflammation and helps reduce uterine contractions. Magnesium supports muscle relaxation and reduces tension, while Vitamin B Complex aids in energy production and mood stabilization. The unique blend works to calm pain amplifiers at their source, helping ease cramps without the side effects associated with traditional painkillers.
* See Study References
The Women Behind monthlies
Formulated with Decades
of Hands-on Experience
Formulated with Decades
of Hands-on Experience
Dr. Ashley Florestal
B. Comm, ND, Canadian College of
Naturopathic Medicine, Concordia University
“What I love about monthlies is its comprehensive yet targeted approach. The formula doesn’t just support with period pain — it nourishes the entire hormonal system. My patients often share that they experience less intense periods, better sleep, improved energy, and more stable moods. This is the power of effectively supporting women’s bodies and hormones."
Dr. Ashley Florestal
B. Comm, ND, Canadian College of Naturopathic Medicine, Concordia University
“What I love about monthlies is its comprehensive yet targeted approach. The formula doesn’t just support with period pain — it nourishes the entire hormonal system. My patients often share that they experience less intense periods, better sleep, improved energy, and more stable moods. This is the power of effectively supporting women’s bodies and hormones."
Dr. Maria Obando
MD, Esp, IFMCP-
Los Andes University
“The HPO axis—your hypothalamus, pituitary, and ovarian system—is the foundation of hormonal health. monthlies supports this vital system with 26 science-backed, natural ingredients, addressing root causes of symptoms like period pain, bloating, fatigue, and mood swings. It truly is a one-stop solution for menstrual wellness.”
Dr. Cassandra Paiano
BSc, ND
“No two women experience their cycles the same way, which is why I appreciate the versatility of monthlies. Its formula is designed to address a variety of symptoms—from period pain and digestive discomfort to lack of energy and mood swings. This adaptability makes it a comprehensive solution for women seeking better menstrual health.”
Geneva Sade
DipNT, mANP, The College of Naturopathic Medicine
“No two women experience their cycles the same way, which is why I appreciate the versatility of monthlies. Its formula is designed to address a variety of symptoms—from period pain and digestive discomfort to lack of energy and mood swings. This adaptability makes it a comprehensive solution for women seeking better menstrual health.”
Melissa Mastroberardino
RHN, ND, Canada College of Natural Nutrition, Concordia University
“It’s astonishing how many women believe period pain is normal and ‘just part of being a woman.’ When women think of health, they often focus on weight, digestion, or skin, but rarely on cycles. monthlies takes a fresh approach by prioritising menstrual wellness, helping women understand their cycles while supporting their bodies to restore balance naturally.”
Fast and free 1 to 2 day shipping
The Ingredients That Make It Work
Why monthlies Is Unlike Any Other Supplement for Menstrual Pain and Health
monthlies is packed with 26 premium, UK-sourced ingredients in their most active (Methazidex) form — more than any other menstrual health supplement. Its powder-to-liquid format ensures up to 200% better absorption than pills and gummies.
With monthlies, you don’t need to worry about taking anything else — you’re covered on all fronts.
Lemon Balm
Supports relaxation and helps manage stress. Known to promote a calm mood and aid in reducing occasional bloating.*
Broccoli Seed Extract
Supports estrogen metabolism and hormonal balance. Promotes comfort during hormonal fluctuations.*
Ginger Root Extract
Reduces menstrual cramps and digestive discomfort by inhibiting prostaglandin synthesis via COX and LOX pathways.*
Aniseed Extract
Relaxes gastrointestinal muscles to reduce bloating and cramps, while modulating prostaglandin pathways.*
Turmeric Root Extract
Turmeric targets inflammation and prostaglandin pathways, reducing discomfort and bloating.*
B1, B2, B3, B5, B6, B7, B9, B12
Targets energy production, hormone regulation, and mood stability, promoting optimal metabolic processes and cognitive function.*
Flaxseed
Rich in lignans that support hormone balance and menstrual cycle regularity. Helps reduce cravings and manage appetite fluctuations.*
Vitamin D3 + K2
Supports bone health and calcium metabolism. Promotes hormone balance and overall strength.*
Vitamin A
Contributes to skin health and hormonal balance. Helps maintain a radiant complexion and support overall wellbeing.*
Magnesium
Promotes muscle relaxation and supports energy metabolism. Helps reduce cramping and manage occasional bloating.*
Calcium
Supports muscle and nerve function while helping regulate mood and manage uterine tension.*
Zinc
Supports hormone regulation and skin health. Helps maintain clear skin and balanced hormone levels.*
Iron
Essential for energy production and oxygen transport. Helps reduce fatigue and support vitality.*
Chromium
Supports blood sugar regulation and helps manage appetite. Also aids in reducing food cravings.*
Selenium
Provides antioxidant support and promotes cellular health. Helps protect against oxidative stress.*
Myo-Inositol
Supports hormonal balance and insulin sensitivity. Aids in promoting regular cycles and reducing cravings.*
Choline
Supports relaxation and helps manage stress. Known to promote a calm mood and aid in reducing occasional bloating.*
Beta-Carotene
Supports skin health and hormone regulation. Helps maintain a radiant complexion and overall wellness.*
L-Glutamine
Supports digestive function and comfort. Helps reduce occasional bloating and maintain gut health.*
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
Choose Your Package Below
Monthly Subscription
SAVE 33%
Tropical Flavour
Month’s supply of monthlies
Save 33% every single month
90-day money back guarantee
FREE shipping on every order
FREE 1-1 doctor consultation
every month (worth £100)
FREE exercise, nutrition, and
cycle guide (worth £50)
Cancel anytime
Delivered every 30 days (free shipping).
£36.00 (£50.00)
Cancel at any time - Free returns - Instant refunds
One-time Purchase
Tropical Flavour
NO money back guarantee
Month’s supply of monthlies
FREE shipping on your order
FREE exercise, nutrition, and
cycle guide (worth £50)
£50.00
Cancel at any time - Free returns - Instant refunds
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monthlies cycle companion
A natural, science-backed dietary supplement with 26+ health-expert-chosen ingredients to support menstrual pain and hormonal health — in a delicious tropical flavour. Complement your daily routine with our women’s health expert-designed formula. From period pain to 360° wellness, all in just one scoop.
Ease intense monthly cramps naturally*
Reduce mood swings, bloating, and PMS*
86% saw improved cycle health in 30 days*
The most complete women's health formula
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How to use
Take monthlies once daily in the morning with food or without. Simply mix one scoop with water or your favourite beverage. Consistent use is essential to experience the full benefits, as it works with your body’s natural cycles.*
Subscription details
You’ll receive a 30-day supply of Monthlies every month. You can cancel anytime — even before your first order runs out. No hassle, no strings attached.
Frequently Asked Questions
How fast will I see results?
Most women notice improvements in energy, mood, and digestion within the first few weeks. Because hormones operate on intricate feedback loops, more significant changes, like potential ease from cramps or bloating, often require 2-3 cycles. This allows monthlies to work with your body’s natural rhythms for lasting results.
How long will today’s special pricing and free gifts be available?
We can’t guarantee today’s special pricing and free gifts will be available beyond midnight. Once word spreads, these exclusive offers tend to go fast. Once it’s gone, it’s gone!
What if I only struggle with X but not Y or Z?
monthlies is designed to address both current symptoms and long-term hormonal health. Many women report feeling more balanced, energetic, and focused within weeks, even if they initially only struggled with one or two “main” symptoms. Its targeted nutrients also work to prevent future flare-ups or new issues from arising, supporting overall well-being.*
Can I start taking it at any point of my cycle?
Yes, you can start taking monthlies at any point in your cycle.
What does the 90-day guarantee mean?
Most women notice an energy boost from Monthlies within days, then experience fewer and less intense cramps, less bloating, more stable moods, and better sleep during their second cycle after starting. Some feel these changes sooner, others might take a bit longer – as every woman’s cycle is unique.
That’s why we encourage you to try it yourself. If you don’t feel more energized and in control, with less bloating and pain, you have 90 days to claim a full refund of your first order. To be eligible, you’ll need to have tried Monthlies for 90 days (i.e. purchased three consecutive monthly subscriptions). Simply email us at returns@withmonthlies.com without giving any further reason.
Can I take monthlies if I use birth control?
While you can certainly take monthlies powder for its potential benefits, it's important to note that hormonal contraceptives, such as implants and pills, can affect hormone levels.
Since hormonal contraceptives regulate your hormone balance, the efficacy of the powder might be compromised by the contraceptive method you are using.
Hear from the women
in our community
This breakthrough moisturiser is powered by Phyaluronic™ Acid, the world’s first and only plant-based alternative to hyaluronic acid that is scientifically proven to mimic your skin’s natural structure perfectly.
With top laboratories around the world seeking this innovation, you can now get it directly from the source, us!
Nourish delivers deep hydration, boosts collagen production, minimises visible signs of aging, helps prevent new fine lines and wrinkles, and strengthens your skin barrier for a plump, youthful glow that lasts.
Suitable for all skin types and tones.
Select the size:
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
What to expect
Your first cycle
What to expect:
In the first cycle, your body starts replenishing key nutrients, supporting steadier energy, better sleep, and a more balanced mood. Early hormonal adjustments can also begin easing bloating and digestive sluggishness, as oestrogen metabolism and fluid regulation start to normalise. These initial shifts set the stage for deeper hormonal recalibration in the coming months, as your body regulates through complex endocrine feedback loops.*
We've accounted for
periods as a whole
Carefully picked by women’s health experts, monthlies features premium, third-party tested ingredients in their most active and highly absorbable forms — ensuring purity, potency, and unmatched quality.
To fit all 26 ingredients in pill form, you'd need to take 16 pills a day. monthlies is the simplest, safest, and most effective way to ensure you're getting everything you need — for less than £1.30 per day at the lowest.
Simply mix one scoop of monthlies into water in the morning, and you’re good to go!
Plant Extracts
Lemon Balm
Lemon balm has been shown to promote relaxation and reduce stress by modulating mood and cognitive function. It may exert calming effects on the central nervous system, potentially through its influence on GABAergic activity.*
Helps: Promotes a calm mood, supports relaxation, and aids in managing occasional bloating.*
Broccoli Seed Extract
Broccoli seed extract contains glucoraphanin, which metabolizes into sulforaphane. Sulforaphane influences estrogen metabolism by promoting a favorable 2:16 hydroxyestrone ratio, supporting hormonal detoxification and balance.*
Helps: Encourages hormonal balance, supports estrogen metabolism, and promotes comfort during hormonal fluctuations*
Flaxseed
Flaxseed is rich in lignans, which act as phytoestrogens. These compounds may help modulate estrogen levels, support progesterone balance during the luteal phase, and improve menstrual cycle regularity. Additionally, flaxseed may help manage weight swings and reduce cravings and appetite fluctuations associated with hormonal changes. The high fiber content in flaxseed promotes satiety, potentially leading to decreased calorie intake and better appetite control.*
Helps: Supports hormonal balance, aids in managing occasional bloating, promotes menstrual cycle comfort, and may assist in weight management by reducing cravings and appetite fluctuations.*
Ginger Root Extract
Ginger contains bioactive compounds like gingerols and shogaols that inhibit prostaglandin synthesis via COX and LOX pathways. This anti-inflammatory action helps reduce menstrual cramps and digestive discomfort.
Helps: Aids in managing occasional cramps, supports digestive wellness, and promotes natural cycle comfort.*
Aniseed Extract
Aniseed has carminative and antispasmodic properties that relax gastrointestinal muscles, alleviating bloating, cramps, and other digestive discomforts.
Helps: Promotes soothing comfort during cyces, supports digestion, and eases occasional tension.*
Turmeric Root Extract
Curcumin in turmeric has anti-inflammatory properties that help reduce menstrual discomfort by targeting inflammatory pathways and promoting bile production to alleviate bloating.*
Helps: Promotes comfort during cycles, supports natural inflammation balance, and aids in managing bloating.*
Vitamin Complex
Vitamin B Octa-Complex (B1, B2, B3, B5, B6, B7, B9, B12)
Contributes to energy production, hormone regulation, and mood support.*
Helps: Boosts energy, stabilises mood, and supports healthy hormone function.*
Vitamin C
Supports skin health and immune system function.*
Helps: Promotes healthier skin and helps protect against oxidative stress.*
Vitamin D3 + K2
Known to support bone health and calcium metabolism.*
Helps: Strengthens bones and supports hormone balance.*
Vitamin A
Contributes to skin clarity and overall health.*
Helps: Supports clearer skin and assists in healthy hormonal function.*
Minerals
Magnesium
Known for its role in muscle relaxation and energy support.*
Helps: Promotes muscle comfort, aids in managing occasional bloating, and encourages relaxation.*
Calcium
Supports muscle and nerve function while helping regulate mood.*
Helps: Eases uterine tension and supports mood stability.*
Zinc
Plays a role in hormone regulation and skin health.*
Helps: Promotes clear skin, healthier hair, and hormone balance.*
Iron
Essential for energy production and oxygen transport.*
Helps: Supports energy levels and reduces fatigue.*
Chromium
Aids in blood sugar regulation and appetite control.*
Helps: Supports reduced cravings and balanced energy levels.*
Selenium
Provides antioxidant support for overall cellular health.*
Helps: Protects cells from oxidative stress and supports healthy nails and hair.*
Nutrients
Myo-Inositol
Myo-inositol is a naturally occurring compound that plays a vital role in cellular signaling and hormone response. It helps support insulin sensitivity and proper glucose metabolism, which may contribute to hormonal balance and regular ovulation. Additionally, myo-inositol aids in maintaining healthy hormone receptor function and cellular communication pathways essential for reproductive health.*
Helps: Supports hormonal balance, promotes regular cycles, aids in maintaining healthy insulin function, and may help manage occasional cravings and appetite fluctuations.*
Choline
Helps support brain and hormonal health.*
Helps: Enhances focus and contributes to hormonal balance.*
Beta-Carotene
A precursor to vitamin A, supporting skin and hormonal health.*
Helps: Contributes to a radiant complexion and supports overall balance.*
Amino Acids
L-Glutamine
Supports gut function and helps maintain digestive comfort.*
Helps: Promotes digestive well-being and supports occasional bloating relief.*
See Full Ingredients
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NON-GMO
NUT-FREE
NO SUGAR
ADDED
GLUTEN
-FREE
PALEO FRIENDLY
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
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Finally: A Company That Ensures Your Success
We're transforming women's wellness by combining science-backed ingredients with expert guidance from professionals who understand. Access proven protocols, get personalized support, and target both root causes and symptoms.
SUBSCRIPTION
1. Monthly 1-1 Consultation
Connect directly with our women's health professionals - the same ones who've helped 2,500 women transform their cycle wellness. Get exclusive guidance from your couch, on your schedule.
Consult our wellness experts privately
Monthly 30-min call at your convenience
Personalized tips beyond supplements
Booking details sent via email after subscribing. Consultations are optional, but we include them because we understand how often period concerns get overlooked.
Fast and free 1 to 2 day shipping
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
360° Support
Doctor-Formulated
Made in the UK
GMP Certified
No PFAs
No Sugar
FAQS
How fast will I see results?
Most women notice improvements in energy, mood, and digestion within the first few weeks. Because hormones operate on intricate feedback loops, more significant changes, like potential ease from cramps or bloating, often require 2-3 cycles. This allows monthlies to work with your body’s natural rhythms for lasting results.
How long will today’s special pricing and free gifts be available?
We can’t guarantee today’s special pricing and free gifts will be available beyond midnight. Once word spreads, these exclusive offers tend to go fast. Once it’s gone, it’s gone!
When and how should I take monthlies?
Take monthlies once daily in the morning with food. Simply mix one scoop with water or your favourite beverage. Consistent use is essential to experience the full benefits, as it works with your body’s natural cycles.*
What if I only struggle with X but not Y or Z?
monthlies is designed to address both current symptoms and long-term hormonal health. Many women report feeling more balanced, energetic, and focused within weeks, even if they initially only struggled with one or two “main” symptoms. Its targeted nutrients also work to prevent future flare-ups or new issues from arising, supporting overall well-being.*
Can I start taking it at any point of my cycle?
Yes, you can start taking monthlies at any point in your cycle.
What does the 90-day guarantee mean?
Most women notice an energy boost from Monthlies within days, then experience fewer and less intense cramps, less bloating, more stable moods, and better sleep during their second cycle after starting. Some feel these changes sooner, others might take a bit longer – as every woman’s cycle is unique.
That’s why we encourage you to try it yourself. If you don’t feel more energized and in control, with less bloating and pain, you have 90 days to claim a full refund of your first order. To be eligible, you’ll need to have tried Monthlies for 90 days (i.e. purchased three consecutive monthly subscriptions). Simply email us at returns@withmonthlies.com without giving any further reason.
Can I take monthlies if I use birth control?
While you can certainly take monthlies powder for its potential benefits, it's important to note that hormonal contraceptives, such as implants and pills, can affect hormone levels.
Since hormonal contraceptives regulate your hormone balance, the efficacy of the powder might be compromised by the contraceptive method you are using.
Disclaimer:
The information provided on this website, through our products, and during consultations is intended for general wellness and educational purposes only. This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition. The claims made here have not been evaluated by any regulatory authority.
Our health professionals and consultations are designed to provide general wellness guidance and should not replace advice from your healthcare provider. Always consult with a physician, pharmacist, or other qualified healthcare professional for questions regarding your health, medications, or specific medical conditions.
Important Information on Use:
1. Results may vary based on individual factors such as starting health, lifestyle, adherence to recommendations, and other unique circumstances.
2. Proper diet, exercise, and hydration are essential for achieving and maintaining health benefits.
3. If you are pregnant or breastfeeding, It is not recommended to take monthlies.
Study References:
The impact of menstrual symptoms on everyday life: a survey among 42,879 women Harlow, S. D., & Park, M. (1996). American Journal of Obstetrics and Gynecology, 174(2), 683-689. https://www.ajog.org/article/S0002-9378(19)30427-2/abstract
NSAID Resistance in Dysmenorrhea: Epidemiology, Causes, and Treatment Options "A review of 51 clinical trials found that 18% of women report minimal or no relief of menstrual pain with NSAIDs." https://pmc.ncbi.nlm.nih.gov/articles/PMC5839921/
NSAID use is associated with increased risk of acute kidney injury, particularly in older adults and those with chronic conditions. https://bjgpopen.org/content/6/1/BJGPO.2021.0208.long
Women with dysmenorrhea using NSAIDs had a 2.29-fold higher risk of stroke with prolonged use (≥24 days/month). https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0259047
32% of women using NSAIDs for period pain reported gastrointestinal side effects, including nausea, ulcers, and diarrhea." https://bmjopen.bmj.com/content/14/6/e079660
Stanford University researchers found that ibuprofen use during ultramarathons doubled the risk of acute kidney injury compared to a placebo. For every five runners taking ibuprofen, one additional case of kidney injury occurred. https://med.stanford.edu/news/all-news/2017/07/pain-reliever-linked-to-kidney-injury-in-endurance-runners.html
Chronic Stress and Ovulatory Dysfunction: Implications in Times of COVID-19 Vigil, P., Meléndez, J., Soto, H., Petkovic, G., Bernal, Y. A., & Molina, S. (2022). Frontiers in Global Women's Health, 3, Article 866104. https://www.frontiersin.org/journals/global-womens-health/articles/10.3389/fgwh.2022.866104/full
Micronutrient deficiencies among women of reproductive age: a global and regional assessment Kothari, M. T., et al. (2024). The Lancet Global Health, 12(1), e76-e84. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00276-6/fulltext
Houston, B. L., Hurrie, D., Graham, J., Perija, B., Rimmer, E., Rabbani, R., Bernstein, C. N., Turgeon, A. F., Fergusson, D. A., Houston, D. S., Abou-Setta, A. M., & Zarychanski, R. (2018). Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials. BMJ Open, 8(4), e019240. https://bmjopen.bmj.com/content/8/4/e019240
Ebrahimi, E., Khayati Motlagh, S., Nemati, S., Tavakoli, Z., & Hojat Yar, M. (2012). Effects of magnesium and vitamin B6 on the severity of premenstrual syndrome symptoms. Journal of Caring Sciences, 1(4), 183–189. https://pmc.ncbi.nlm.nih.gov/articles/PMC4161081/
Fathizadeh, N., Ebrahimi, E., Valiani, M., Tavakoli, N., Hojat Yar, M., & Hojat Yar, M. (2010). Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iranian Journal of Nursing and Midwifery Research, 15(Suppl1), 401–405. https://pmc.ncbi.nlm.nih.gov/articles/PMC3208934/#ref5
Wyatt, K. M., Dimmock, P. W., Jones, P. W., & O'Brien, P. M. (1999). Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ, 318(7195), 1375–1381. https://pmc.ncbi.nlm.nih.gov/articles/PMC27878/#sec14
James W. Daily, Ph.D., Xin Zhang, BS, Da Sol Kim, MS, Sunmin Park, Ph.D., Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials, Pain Medicine, Volume 16, Issue 12, December 2015, Pages 2243–2255, https://doi.org/10.1111/pme.12853
Rose, D. P. (1978). The interactions between vitamin B6 and hormones. Vitamins and Hormones, 36, 53–99. https://pubmed.ncbi.nlm.nih.gov/217175/
See all here.